An issue that I currently face is creating prototypes with an integrated day and night mode. I often need to test the same thing in both conditions, and I currently need to have a hidden layer that is getting affected by inputs etc and is then made visible when a mode switch is requested. This is obviously quite time consuming and is a bit of a nightmare should anything change. Perhaps having version of a swatch might help with this and you can call for a different swatch set that is tied to another swatch set?